6-CHLORO-1H-INDOLE-2-CARBALDEHYDE Chemical Properties

Boiling point:

373.4±22.0 °C(Predicted)

Density 

1.431±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

14.15±0.30(Predicted)

Appearance

Light yellow to brown Solid

Safety Information

HS Code 

29339900

6-CHLORO-1H-INDOLE-2-CARBALDEHYDE Usage And Synthesis

Chemical Properties

Brown solid

Synthesis

GENERAL STEPS: A suspension of 2-hydroxymethyl-6-chloroindole (1 mmol) with activated MnO2 (10 mmol) in DMF (30 mL) was stirred at room temperature for 12 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated under vacuum and the residue was purified by column chromatography to afford 6-chloro-1H-indole-2-carbaldehyde using EtOAc-hexane mixed solvent as eluent.

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 561 - 577
[2] Patent: US2003/144282, 2003, A1
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1380 - 1400
[4] Patent: US2008/9485, 2008, A1. Location in patent: Page/Page column 31
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 2, p. 364 - 377

6-CHLORO-1H-INDOLE-2-CARBALDEHYDE(53590-59-3)Related Product Information

• 4,6-DICHLORO-1H-INDOLE-2-CARBONYL CHLORIDE
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• 6-Chloroindole-2-carboxylic acid
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• 6-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER
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• ETHYL 4,6-DICHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE
• 6,7-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
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• (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
• ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE
• 6-CHLORO-4-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID
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• ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL
• 1H-INDOLE-2-CARBOXYLIC ACID,6-CHLORO-4-FLUORO-3-FORMYL-,ETHYL ESTER
• 1-(beta-Dimethylaminoaethyl)-2-ethoxycarbonyl-3-ethoxy-6-chlor-indol-t oluol-4-sulfonat
• 4,6-DICHLORO-3-HYDROXYMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER