ABT-888
ABT-888 Basic information
- Product Name:
- ABT-888
- Synonyms:
-
- ABT-888
- 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide,dihydrochloridesalt
- 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
- Veliparib dihydrochloride
- ABT-888(Veliparib dihydrochloride)
- ABT-888 dihydrochloride
- ABT888 HCl
- Veliparib hydrochloride
- CAS:
- 912445-05-7
- MF:
- C13H16N4O
- MW:
- 244.296
- EINECS:
- 1592732-453-0
- Product Categories:
-
- Inhibitors
- Inhibitor
- API
- Mol File:
- 912445-05-7.mol
ABT-888 Chemical Properties
- Melting point:
- >173°C (dec.)
- storage temp.
- Refrigerator
- solubility
- Methanol (Slightly, Heated), THF (Slightly, Heated)
- form
- Colorless to white crystalline solid.
- color
- Off-White to Dark Yellow
ABT-888 Usage And Synthesis
Uses
ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.
in vivo
The oral bioavailability of Veliparib is 56%-92% in mice, SD rats, beagle dogs, and cynomolgus monkeys after oral administration[1]. Veliparib (25 mg/kg, i.p.) can improve tumor growth delay in a NCI-H460 xenograft model. Combination with radiation, veliparib decreases the tumor vessel formation[3]. Veliparib reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression can be maintained over time[4].
IC 50
PARP-2: 2.9 nM (Ki); PARP-1: 5.2 nM (Ki)
storage
Store at -20°C
ABT-888Supplier
- Tel
- sales@boylechem.com
- Tel
- 18858184290; 18858184290
- sales@zyterpharm.com
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 021-58099652-8005 13585536065
- bin.wu@shlschem.com
- Tel
- 86-0571-85151182
ABT-888(912445-05-7)Related Product Information
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- PLX4032
- 4-AMINO-1,8-NAPHTHALIMIDE
- 3-Aminobenzamide
- NU1025
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- DPQ
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- Velpatasvir