4-Cyano-3-methylBenzoic acid methyl ester Chemical Properties

Boiling point:

311.8±30.0 °C(Predicted)

Density 

1.15

storage temp. 

Sealed in dry,Room Temperature

Appearance

Off-white to brown Solid

Safety Information

HS Code 

2926907090

4-Cyano-3-methylBenzoic acid methyl ester Usage And Synthesis

Synthesis

11A: Synthesis of methyl 4-bromo-3-methylbenzoate Zinc cyanide (6.2 g, 52 mmol) and tetrakis(triphenylphosphine)palladium(0) (4 g, 3 mmol) were added to a solution of methyl 4-bromo-3-methylbenzoate (20 g, 87 mmol) in DMF (100 mL). The reaction mixture was stirred at 120 °C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with EtOAc (700 mL) and washed sequentially with water and brine. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography (silica gel, eluent ratio 1:3 EtOAc:hexane) afforded methyl 4-cyano-3-methylbenzoate (12.3 g, 39.8% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 2.59 (s, 3H), 3.93 (s, 3H), 7.66 (d, J=8.0 Hz. 1H), 7.90 (d, J=8.0Hz, 1H), 7.97 (s, 1H).

References

[1] Patent: US2007/270438, 2007, A1. Location in patent: Page/Page column 42
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3679 - 3683
[3] Patent: WO2007/79186, 2007, A2. Location in patent: Page/Page column 59

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