Artemether Chemical Properties

Melting point:

86-88°C

Boiling point:

359.79°C (rough estimate)

alpha 

D19.5 +171° (c = 2.59 in CHCl3)

Density 

1.0733 (rough estimate)

refractive index 

1.6200 (estimate)

storage temp. 

room temp

solubility 

DMSO: ≥20mg/mL

form 

powder

color 

off-white to light brown

optical activity

[α]/D +155 to +175°, c = 0.5 in methanol

Merck 

14,815

InChI

InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

InChIKey

SXYIRMFQILZOAM-HVNFFKDJSA-N

SMILES

O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

3

RTECS 

KD4165000

HS Code 

29329930

Hazardous Substances Data

71963-77-4(Hazardous Substances Data)

Toxicity

LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu)

MSDS

• Language:English Provider:[3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin

Artemether Usage And Synthesis

Description

Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC₅₀s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD₅₀) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.

Chemical Properties

White Solid

Uses

Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.

Uses

atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist

Uses

Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when

Definition

ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.

General Description

Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.

Biochem/physiol Actions

Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.

Safety Profile

Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.

target

Antifection

storage

Store at -20°C

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