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Artemether

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Artemether Basic information

Product Name:
Artemether
Synonyms:
  • methyl-dihydroartemisinine
  • [3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin
  • ARTEMETHER
  • ARTHEMETER
  • Artimether
  • ArtemetherC16H26O5
  • cgp56696
  • dihydroartemisininmethylether
CAS:
71963-77-4
MF:
C16H26O5
MW:
298.37
EINECS:
663-549-0
Product Categories:
  • Chiral Reagents
  • Heterocycles
  • Antimalarial
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • chemical reagent
  • Herb extract
  • Inhibitor
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • PALUTHER
  • natural product
  • API
  • 71963-77-4
Mol File:
71963-77-4.mol
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Artemether Chemical Properties

Melting point:
86-88°C
Boiling point:
359.79°C (rough estimate)
alpha 
D19.5 +171° (c = 2.59 in CHCl3)
Density 
1.0733 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
off-white to light brown
optical activity
[α]/D +155 to +175°, c = 0.5 in methanol
Merck 
14,815
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
RTECS 
KD4165000
HS Code 
29329930
Hazardous Substances Data
71963-77-4(Hazardous Substances Data)
Toxicity
LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu)
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Artemether Usage And Synthesis

Description

Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.

Chemical Properties

White Solid

Uses

Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.

Uses

atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist

Uses

Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when

Definition

ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.

General Description

Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.

Biochem/physiol Actions

Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.

Safety Profile

Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.

target

Antifection

storage

Store at -20°C

Artemether Preparation Products And Raw materials

Preparation Products

ArtemetherSupplier

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