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JNJ-26481585

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JNJ-26481585 Basic information

Product Name:
JNJ-26481585
Synonyms:
  • JNJ-26481585
  • N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diaMine
  • N-Hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide
  • N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-carbox
  • N-Hydroxy-2-(4-((((1-Methyl-1H-indol-3-yl)Methyl)aMino)Methyl)piperidin-1-yl)pyriMidine-5-carboxaMide
  • Quisinostat (JNJ-26481585)
  • Quisinostat
  • N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-car
CAS:
875320-29-9
MF:
C21H26N6O2
MW:
394.47
Product Categories:
  • Inhibitors
  • Inhibitor
Mol File:
875320-29-9.mol
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JNJ-26481585 Chemical Properties

Density 
1.35
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥19.2 mg/mL in DMSO
form 
Powder
color 
Off-white to yellow
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JNJ-26481585 Usage And Synthesis

Uses

JNJ-26481585 is an HDAC1, HDAC2, HDAC4, HDAC10, and HDAC11 inhibitor. Potent Histone deacetylase inhibitor.

Definition

ChEBI: N-hydroxy-2-[4-[[(1-methyl-3-indolyl)methylamino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide is a member of indoles.

Biological Activity

jnj-26481585 is a novel histone deacetylase (hdac) inhibitor that exerts a strong potency towards class i hdac (including hdac1, hdac2 and hdac3), with values of inhibition constant ic50 of 0.11, 0.33 and 4.8 nmol/l respectively, leading to strong anti-proliferative activities (ic50 ranging from 3.1 to 246 nmol/l) against a broad range of cancer cell lines including lung, breast, colon, prostate, brain and overian cancer cell lines. recent study results have shown that jnj-26481585 strongly induce the hdac1-suppressed p21waf1,cip1 promoter in vivo, histone h3 acetylation in tumor tissue and apoptosis in human colon cancer cell lines (both apc wild-type and mutant) in vitro.arts j, king p, mariën a, floren w, beliën a, janssen l, pilatte i, roux b, decrane l, gilissen r, hickson i, vreys v, cox e, bol k, talloen w, goris i, andries l, du jardin m, janicot m, page m, van emelen k, angibaud p. jnj-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. clin cancer res. 2009;15(22):6841-6851

target

HDAC1

JNJ-26481585Supplier

Jinan Jiuli Biotechnology Co. , Ltd. Gold
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15865264761
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486064515@qq.com
Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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meilunui@163.com
Chengdu NoVi Biotechnology Co., Ltd.
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028-81458053
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novibiotech@163.com sales@novi-biotech.com
NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988