(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Chemical Properties

storage temp. 

-20°C

solubility 

DMSO: ≥12mg/mL

form 

powder

color 

white to tan

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Usage And Synthesis

Uses

Antidepressant; antianxiety.

General Description

(2S,3S)-hydroxybupropion is a major metabolite of bupropion.

Biochem/physiol Actions

(2S,3S)-hydroxybupropion is a dopamine transporter (DAT) and norepinephrine transporter (NET) transporters inhibitor and nicotinic acetylcholine receptor (nAChR) family modulator. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in nicotine-dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of nicotine reward in mice.

(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol(106083-71-0)Related Product Information

• Bupropion
• 2-(TERT-BUTYLAMINO)PROPIOPHENONE HYDROCHLORIDE
• 2-(tert-ButylaMino)-3',5'-chloropropiophenone hydrochloride
• 1-(3-Chlorophenyl)-2-hydroxy-1-propanone
• Bupropion Hydrochloride
• Bupropion Hydrochloride Related Compound B (15 mg) (2-(tert-butylamino)-3'-bromopropiophenone hydrochloride)
• 2-(tert-ButylaMino)-3',4'-chloropropiophenone hydrochloride
• Bupropion Hydrochloride Related Compound A (15 mg) (2-(tert-butylamino)-4'-chloropropiophenone hydrochloride)
• 2-(tert-ButylaMino)-2'-chloropropiophenone Hydrochloride
• (R,R)-Hydroxy Bupropion