Abacavir Carboxylate Chemical Properties

Melting point:

208-210°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

form 

Solid

color 

Off-White to Pale Beige

Stability:

Hygroscopic

Abacavir Carboxylate Usage And Synthesis

Description

Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.

Chemical Properties

Off-White Solid

Uses

Abacavir Carboxylate (Abacavir - In House Impurity) is a major metabolite of Abacavir (A105000) in human urine and cerebrospinal fluid (1,2,3).

Definition

ChEBI: Abacavir 5'-carboxylic acid is a monocarboxylic acid oxidation product of abacavir, in which the C-5' hydroxymethyl group has been oxidised to a carboxy group. One of the two major metabolites of abacavir in humans (the other is the 5'-glucuronide, CHEBI:64189). It has a role as a metabolite. It is functionally related to an abacavir.

Abacavir Carboxylate(384380-52-3)Related Product Information

• 2,6-Diaminopurine
• trans-Abacavir Hydrochloride
• Abacavir
• Abacavir
• (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
• (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol
• Abacavir sulfate
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)-
• Abacavir
• 2-Amino-6-cyclopropylamino-9H-purine
• Abacavir
• Abacavir 5'-Glucuronide
• Abacavir 5’-Phosphate
• Abacavir Related CoMpound D
• Abacavir-d4
• (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride
• 6-aminocarbovir
• Abacavir Impurity 1