ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > GPCR & G Protein > CGRP Receptor Antagonists > MK 3207 hydrochloride
MK 3207 hydrochloride
MK 3207 hydrochloride Basic information
- Product Name:
- MK 3207 hydrochloride
- Synonyms:
-
- MK3207 HYDROCHLORIDE;MK 3207 HYDROCHLORIDE;MK-3207
- 2-((R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide hydrochloride
- CS-549
- (8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride
- MK 3207 hydrochloride
- MK-3207 HCl salt
- MK3207 HCl
- 6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride
- CAS:
- 957116-20-0
- MF:
- C31H30ClF2N5O3
- MW:
- 594.06
- EINECS:
- 200-258-5
- Product Categories:
-
- Inhibitors
- Mol File:
- 957116-20-0.mol
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MK 3207 hydrochloride Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Off-white to pink
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MK 3207 hydrochloride Usage And Synthesis
Uses
MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.
Biological Activity
MK-3207 HCl is a potent CGRP receptor antagonist with IC50 and Ki of 0.12 nM and 0.022 nM, respectively, with high selectivity for human AM1, AM2, CTR, and AMY3. Phase 2.
in vivo
MK-3207 is CNS-penetrant and therefore significantly engaging central receptors. After an oral dose of 10 mg/kg MK-3207, the CSF/plasma ratio is 2 to 3%[1].
References
[1] Salvatore CA, et al. Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60. DOI:10.1124/jpet.109.163816
MK 3207 hydrochlorideSupplier
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