Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  DNA damage >  PARP inhibitors >  5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Basic information Safety Supplier Related

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Basic information

Product Name:
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
Synonyms:
  • 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
  • UPF 1069
  • 5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone
  • 1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-
  • UPF 1069;UPF-1069; UPF1069
  • UPF 1069 10MG
  • UPF1069/UPF-1069
  • CS-874
CAS:
1048371-03-4
MF:
C17H13NO3
MW:
279.29
Product Categories:
  • Inhibitors
  • Inhibitor
Mol File:
1048371-03-4.mol
More
Less

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties

storage temp. 
Store at RT
solubility 
Soluble in DMSO (up to 40 mg/ml).
form 
solid
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
22
More
Less

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Usage And Synthesis

Description

UPF-1069 (1048371-03-4) is a selective PARP-2 inhibitor (IC50=0.3 μM and ~ 27-fold selective against PARP-1).1,2?Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3?Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4

Uses

UPF 1069, is a Selective PARP-2 inhibitor.

References

1) Pellicciari?et al.?(2008),?On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem.,?3?914 2) Thorsell?et al.?(2017),?Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors; J. Med. Chem.,?60?1262 3) Moroni?et al.?(2009),?Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage; Br. J. Pharmacol.,?157?854 4) Gui?et al.?(2019),?Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function; Proc. Natl. Acad. Sci. USA,?116?14573

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-oneSupplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18516978288
Email
sales.gd@hwrkchemical.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
More
Less