Caraphel A
Caraphel A Basic information
- Product Name:
- Caraphel A
- Synonyms:
-
- Caraphel A
- Caraphenol A
- Cyclonona[1,2,3-cd:4,5,6-c'd':7,8,9-c''d'']trisbenzofuran-4,9,14-triol, 2,2a,7,7a-tetrahydro-2,7,12-tris(4-hydroxyphenyl)-, (2R,2aR,7S,7aS)-rel- (9CI)
- CAS:
- 354553-35-8
- MF:
- C42H28O9
- MW:
- 676.67
- Mol File:
- 354553-35-8.mol
Caraphel A Chemical Properties
- form
- Solid
- color
- Light yellow to yellow
Caraphel A Usage And Synthesis
Uses
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells[1]. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively[2].
in vivo
Caraphenol A-treated (30 μM; pretreated for 4 h) HSCs maintain improved gene marking in mice without altering lentiviral integration profiles[1].
References
[1] Ozog S, et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. Blood. 2019 Oct 17;134(16):1298-1311. DOI:10.1182/blood.2019000040
[2] Niu W, et al. Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe. Medchemcomm. 2016 Nov 15;8(1):198-201. DOI:10.1039/c6md00493h
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