Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Chemical Properties

Boiling point:

525.6±50.0 °C(Predicted)

Density 

1.300

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

12.16±0.20(Predicted)

form 

Powder

color 

Light yellow to yellow

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Usage And Synthesis

Uses

CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. IC50 Value: <8 nM [1] Target: CDK9 In vitro: In vivo:

IC 50

CDK9/cyclinT1: 8 nM (IC₅₀)

References

[1] Keith B Pfister, et al. Heteroaryl compounds as kinase inhibitors. 2011, WO2011026917A1.

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide(1269815-17-9)Related Product Information

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