Trifluoromethanesulfonyl chloride Chemical Properties

Melting point:

-26 °C

Boiling point:

29-32 °C (lit.)

Density 

1.583 g/mL at 25 °C (lit.)

vapor pressure 

10.36 psi ( 20 °C)

refractive index 

n20/D 1.334(lit.)

Flash point:

32°C

storage temp. 

2-8°C

solubility 

Chloroform

form 

Liquid

color 

Clear colorless to faintly colored

Specific Gravity

1.583

Water Solubility 

Hydrolyzes with water.

Sensitive 

Lachrymatory

BRN 

1812016

InChIKey

GRGCWBWNLSTIEN-UHFFFAOYSA-N

CAS DataBase Reference

421-83-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

14-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

F 

10-21

Hazard Note 

Corrosive/Lachrymatory

HazardClass 

8

PackingGroup 

II

HS Code 

29049090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Trifluoromethanesulfonyl chloride Usage And Synthesis

Chemical Properties

Clear colorless to faintly colored liquid

Uses

Ru(II) complex-catalyzed trifluoromethylating agent for aromatics and alkenes.

Application

Trifluoromethanesulfonyl chloride can be used as:
A trifluoromethylating agent for the fluoroalkylation of heterocycles, arenes, and heteroarenes.
A sulfonating agent for alcohols.
A chlorinating agent for carbanions.

Synthesis

Add 150g (1mol) of trifluoromethanesulfonic acid to the reactor equipped with thermometer, distillation device and mechanical stirrer, slowly add 435mL (6mol) of thionyl chloride under ice bath, and then add the catalyst N,N-dimethyl Formamide 7.36 (0.1 mol), slowly raise the temperature to room temperature, stir for half an hour, continue to heat up to 40°C, continue to stir, react for 12 hours, and then drop to room temperature after the reaction is complete.Subsequently, vacuum distillation was carried out at 110° C. and -0.1 to -0.08 MPa, and at the same time, the temperature was slowly raised to 50° C. to obtain 147 g of trifluoromethanesulfonyl chloride, with a yield of 87.5%.

Trifluoromethanesulfonyl chloride (421-83-0)Related Product Information

• TRIFLUOROMETHYL SULFINYL CHLORIDE
• (S)-(-)-Trityl glycidyl ether
• Cyhalothrin
• COPPER(II) TRIFLUOROMETHANESULFONATE
• Silver(I) trifluoromethanethiolate
• Silicon monoxide
• Bismuth(III) trifluoromethanesulfonate
• Lithium trifluoromethanesulfonate
• Zinc trifluoromethanesulfonate
• Lanthanum trifluoromethanesulfonate
• Aluminum trifluoromethanesulfonate
• YTTERBIUM(III) TRIFLUOROMETHANESULFONATE HYDRATE
• Sodium trifluoromethanesulfonate
• Trifluoromethanesulfonic anhydride
• SILVER TRIFLUOROMETHANESULFONATE
• Potassium trifluoromethanesulfonate
• Trifluoromethanesulfonic acid
• Sodium trifluoromethanesulfinate