FMoc-NH-5(ethylene glycol)-acetic acid
FMoc-NH-5(ethylene glycol)-acetic acid Basic information
- Product Name:
- FMoc-NH-5(ethylene glycol)-acetic acid
- Synonyms:
-
- Fmoc-PEG5-acetic acid
- 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
- FMoc-NH-5(ethylene glycol)-acetic acid
- FMoc-NH-PEG5-CH2COOH
- 5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
- Fmoc-NH-5(ethylene glycol)-actic acid
- 17-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15-pentaoxaheptadecanoic acid
- {2-[2-(2-{2-[2-(9H-fluoren-9-yl-methoxycarbonylamino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}acetic acid
- CAS:
- 635287-26-2
- MF:
- C27H35NO9
- MW:
- 517.57
- Product Categories:
-
- peg
- Mol File:
- 635287-26-2.mol
FMoc-NH-5(ethylene glycol)-acetic acid Chemical Properties
- Boiling point:
- 704.3±60.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.39±0.10(Predicted)
- form
- Viscous Liquid
- color
- Colorless to light yellow
FMoc-NH-5(ethylene glycol)-acetic acid Usage And Synthesis
Description
Fmoc-NH-PEG5-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Fmoc-NH-PEG5-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Cleavable
| Alkyl/ether
| PEGs
|
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FMoc-NH-5(ethylene glycol)-acetic acid(635287-26-2)Related Product Information
- alpha, oMega-Dipropionic acid triethylene glycol
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- 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL
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- 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-thiol
- HEPTAETHYLENE GLYCOL MONOMETHYL ETHER
- FMOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID
- Fmoc-N-amido-PEG11-acid
- FMoc-NH-8(ethylene glycol)-acetic acid
- Fmoc-N-amido-PEG17-acid
- Fmoc-NH-PEG2-CH2CO2H
- Fmoc-NH-PEG3-CH2COOH
- Fmoc-N-amido-PEG15-acid
- 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid,1-(9-fluren-9-ylmethyl)ester
- FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID
- Fmoc-N-amido-PEG14-acid
- FMoc-NH-PEG9-CH2CH2COOH