H2N-PEG6-tBu Chemical Properties

Boiling point:

475.9±40.0 °C(Predicted)

Density 

1.056±0.06 g/cm3(Predicted)

storage temp. 

-20°C

form 

Oil

pka

8.74±0.10(Predicted)

color 

Colorless to light yellow

Safety Information

HS Code 

2942000090

H2N-PEG6-tBu Usage And Synthesis

Description

Amino-PEG6-t-butyl ester is a PEG reagent containing an amino NH2 group with a t-butyl protected carboxyl group (Boc). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

H2N-PEG6-tBu(1286281-32-0)Related Product Information

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