1,2-PROPANEDIOL-D8 Chemical Properties

Melting point:

-60 °C (lit.)

Boiling point:

187 °C (lit.)

Density 

1.143 g/mL at 25 °C

refractive index 

n20/D 1.432(lit.)

Flash point:

225 °F

CAS Number Unlabeled

57-55-6

Safety Information

WGK Germany 

3

MSDS

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1,2-PROPANEDIOL-D8 Usage And Synthesis

Uses

(±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] De Cock RF, et al. Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Ther Drug Monit. 2014 Jun;36(3):278-87. DOI:10.1097/FTD.0000000000000003

1,2-PROPANEDIOL-D8(80156-55-4)Related Product Information

• 2-NITRO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL,2-(HYDROXYMETHYL)-2-NITRO-1,3-PROPANEDIOL
• 2-METHYL-2-N-PROPYL-1,3-PROPANEDIOL,2-METHYL-2-PROPYL-1,3-PROPANEDIOL
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• 2-ETHYL-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL TRIACRYLATE
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• Trimethylolpropane
• 2-ETHYL-2-METHYL-1,3-PROPANEDIOL,2-METHYL-2-ETHYL-1,3-PROPANEDIOL
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• 2-METHYL-2-PROPYL-1,3-PROPANEDIOL DICARBAMATE
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• 2-ETHYL-3-PROPYL-1,3-PROPANEDIOL
• TRIPROPYLENE GLYCOL MONOMETHYL ETHER
• Pentaerythritol tetrakis(2-mercaptoacetate)