(+)-Cloprostenol isopropyl ester Chemical Properties

Boiling point:

600.0±55.0 °C(Predicted)

Density 

1.227±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Oil

pka

13.41±0.20(Predicted)

color 

Colourless

InChIKey

OCNSAYQJDKJOLH-AHTXBMBWSA-N

SMILES

C(OC(C)C)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COC1=CC=CC(Cl)=C1

(+)-Cloprostenol isopropyl ester Usage And Synthesis

Description

(+)-Cloprostenol is a synthetic analog of prostaglandin F_2α (PGF_2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF_2α in terminating pregnancy when given subcutaneously at a daily dose of 0.125 μg/kg in rats and hamsters, without the side effects associated with PGF_2α. (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC₅₀ value of 3 x 10-12 M. (+)-Cloprostenol isopropyl ester is a more lipid soluble form of cloprostenol.

Uses

(+)-Cloprostenol isopropyl ester is an isopropyl ester derivative of Cloprostenol (C587300); an aryl-oxymethyl analog of prostaglandin F2α.

in vivo

IC 50

FP

References

[1] GINETTE SERRERO  Nancy M L. Prostaglandin F2αReceptor (FP Receptor) Agonists Are Potent Adipose Differentiation Inhibitors for Primary Culture of Adipocyte Precursors in Defined Medium[J]. Biochemical and biophysical research communications, 1997, 233 1: Pages 200-202. DOI: 10.1006/bbrc.1997.6433