N,N-Dimethylpropionamide Chemical Properties

Melting point:

-45 °C (lit.)

Boiling point:

174-175 °C (lit.)

Density 

0.92 g/mL at 25 °C (lit.)

refractive index 

1.438-1.442

Flash point:

63 °C

storage temp. 

Store below +30°C.

form 

Liquid

pka

-0.41±0.70(Predicted)

Specific Gravity

0.920

color 

Colorless

Water Solubility 

SOLUBLE

Dielectric constant

33.1（Ambient）

Stability:

Flammable. Incompatible with strong oxidizing agents.

InChIKey

MBHINSULENHCMF-UHFFFAOYSA-N

CAS DataBase Reference

758-96-3(CAS DataBase Reference)

NIST Chemistry Reference

Propanamide, N,N-dimethyl-(758-96-3)

EPA Substance Registry System

Propanamide, N,N-dimethyl- (758-96-3)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

37/39-26-24/25

WGK Germany 

2

RTECS 

UE3810000

TSCA 

Yes

HS Code 

29241900

MSDS

• Language:English Provider:N,N-Dimethylpropionamide
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N,N-Dimethylpropionamide Usage And Synthesis

Chemical Properties

colourless liquid

Uses

N,N-Dimethylpropionamide has been used in the preparation of AST-type zeolite with a plate morphology. N,N-Dimethylpropionamide is strong donor solvent and coordinate to metal ions through the carbonyl oxygen atom.

Uses

N,N-Dimethylpropionamide has been used in the preparation of AST-type zeolite with a plate morphology.

General Description

Solvation structure of the zinc (II) ion in N,N-dimethylpropionamide was studied by Raman spectroscopy. N,N-Dimethylpropionamide is strong donor solvent and coordinate to metal ions through the carbonyl oxygen atom.

Synthesis

GENERAL METHOD: Carboxylic acid (0.3 mmol), catalyst (5 mol%), Xantphos (10 mol%), K2S2O8 (2 equiv.) and N,N-dimethylformamide (2 mL) were added to a 20 mL reaction tube. After sealing the reaction tube, the mixture was stirred at 160 °C for 12 h or until the reaction was complete. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with hexane-ethyl acetate (1:1, v/v) as eluent.

Purification Methods

Shake the amide over BaO for 1-2 days, then distil it under reduced pressure. [Beilstein 4 III 126.]

References

[1] Tetrahedron, 2016, vol. 72, # 50, p. 8210 - 8214

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