γ-Secretase Inhibitor XXI
γ-Secretase Inhibitor XXI Basic information
- Product Name:
- γ-Secretase Inhibitor XXI
- Synonyms:
-
- γ-Secretase Inhibitor XXI
- N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
- CoMpound E (secretase inhibitor)
- DuPont E
- g-Secretase Inhibitor XXI
- γ-Secretase Inhibitor BZ
- (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
- (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
- CAS:
- 209986-17-4
- MF:
- C27H24F2N4O3
- MW:
- 490.5
- Mol File:
- 209986-17-4.mol
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γ-Secretase Inhibitor XXI Chemical Properties
- Boiling point:
- 778.6±60.0 °C(Predicted)
- Density
- 1.31
- storage temp.
- = -70C
- solubility
- Soluble in DMSO
- form
- Liquid
- pka
- 12.54±0.40(Predicted)
- color
- White to off-white
- Sensitive
- Light Sensitive
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γ-Secretase Inhibitor XXI Usage And Synthesis
Uses
A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing
Definition
ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene.
storage
+4°C
γ-Secretase Inhibitor XXISupplier
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