MK-2048
MK-2048 Basic information
- Product Name:
- MK-2048
- Synonyms:
-
- Pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, 2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxo-, (6S)-
- CS-1529
- (S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-diMethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxaMide
- (6S)-2-[(3-Chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxopyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide
- MK-2048 USP/EP/BP
- MK-2048 MK2048
- CAS:
- 869901-69-9
- MF:
- C21H21ClFN5O4
- MW:
- 461.87
- Product Categories:
-
- Inhibitors
- Mol File:
- 869901-69-9.mol
MK-2048 Chemical Properties
- Density
- 1.55
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 6.30±0.40(Predicted)
MK-2048 Usage And Synthesis
Uses
MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir.
Uses
MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir.
target
subtype B integrase
MK-2048Supplier
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- 010-82848833 400-666-7788
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- 025-58849295 18951903616;
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