MI-3 (Menin-MLL Inhibitor) Chemical Properties

Boiling point:

527.9±60.0 °C(Predicted)

Density 

1.36±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic)

form 

Powder

pka

9.59±0.40(Predicted)

color 

Light yellow to yellow

MI-3 (Menin-MLL Inhibitor) Usage And Synthesis

Description

MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC₅₀ = 648 nM). MI-3 binds to menin (K_d = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC₅₀ = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.

Uses

MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.

MI-3 (Menin-MLL Inhibitor)(1271738-59-0)Related Product Information

• MI-136
• SAR405838 (MI-773)
• MI-2 (Menin-MLL Inhibitor)
• Tazemetostat (EPZ-6438)
• ACY-1215
• Panobinostat
• (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
• I-BET-762
• OG-L002