Nutlin-3b Chemical Properties

Density 

1.36

storage temp. 

Store at -20°C

solubility 

insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO

form 

crystalline solid

pka

14.35±0.20(Predicted)

color 

Off-white to yellow

Nutlin-3b Usage And Synthesis

Description

(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC₅₀ value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.

Uses

Nutlin 3b is a small molecule MDM2 antagonist.

Definition

ChEBI: Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent.

References

[1] tovar c, rosinski j, filipovic z, higgins b, kolinsky k, hilton h, zhao x, vu bt, qing w, packman k, myklebost o, heimbrook dc, vassilev lt. small-molecule mdm2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. proc natl acad sci u s a. 2006 feb 7;103(6):1888-93.
[2] cao c, shinohara et, subhawong tk, geng l, kim kw, albert jm, hallahan de, lu b. radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2. mol cancer ther. 2006 feb;5(2):411-7.

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