Pamoic acid Chemical Properties

Melting point:

≥300 °C (dec.)

Boiling point:

434.1°C (rough estimate)

Density 

1.2472 (rough estimate)

refractive index 

1.4593 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in nitrobenzene, pyridine

form 

Crystalline Powder

pka

2.67±0.30(Predicted)

color 

Yellow to yellow-green

Water Solubility 

PRACTICALLY INSOLUBLE

Merck 

14,7005

BRN 

901319

InChIKey

WLJNZVDCPSBLRP-UHFFFAOYSA-N

CAS DataBase Reference

130-85-8(CAS DataBase Reference)

EPA Substance Registry System

2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy- (130-85-8)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-48-41-37/38-20/21/22

Safety Statements 

26-36-45-36/37/39-22

WGK Germany 

3

RTECS 

QL2180000

TSCA 

Yes

HS Code 

29182990

Toxicity

eye-rbt 100 mg MOD FCTOD7 20,573,82

MSDS

• Language:English Provider:Embonic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Pamoic acid Usage And Synthesis

Chemical Properties

Pamoic acid is yellow to yellow-green crystalline powder

Uses

Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases.

Uses

Pamoic acid is used in preparation of repository derivatives of medicinal agents, used in pharmacology to increase the solubility of a drug in water.

Definition

ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

(1)Pamoic acid can inhibit Cas9 endonuclease activity. It effectively blocks bacterial or mammalian genome editing mediated by SpyCas9, SauCas9 or BE4 base editors at multiple endogenous gene loci. In addition, pamoic acid displays substrate competitive and PAM binding site occupancy mechanisms that selectively inhibit linear DNA cleavage compared to Cas9 cleavage of superhelical DNA. Importantly, pamoic acid pharmacologically modulates Cas9-mediated genome editing in mice.
(2)GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes.

Safety Profile

Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Pamoic acid(130-85-8)Related Product Information

• Ethyl 2-(Chlorosulfonyl)acetate
• Pyrantel pamoate
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• CHLOROPHOSPHONAZO III
• Folic acid
• Stearic acid
• 3-Hydroxybenzoic acid
• Hyaluronic acid
• 2,3,4-Trihydroxybenzoic acid
• Methylparaben
• 2'-Hydroxy-3-phenylpropiophenone
• Benzohydroxamic acid
• Salicylic acid
• Butylparaben
• Nalidixic acid
• 1-Hydroxy-2-naphthoic acid
• Cobalt naphthenate
• Citric acid