SR8278 Chemical Properties

Melting point:

52-55°C

Boiling point:

535.7±50.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: ≥30mg/mL

pka

-3.20±0.40(Predicted)

form 

film

color 

white to tan

Safety Information

WGK Germany 

3

SR8278 Usage And Synthesis

Description

REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC₅₀ = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.

Uses

SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.

storage

Store at +4°C

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