Saxagliptin hydrochloride Chemical Properties

Melting point:

>219°C

storage temp. 

-20°C

solubility 

Soluble in DMSO (20 mg/ml)

form 

solid

color 

White

Stability:

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

InChI

InChI=1/C18H25N3O2.ClH/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H/t10?,11?,12-,13+,14+,15-,17?,18?;/s3

InChIKey

TUAZNHHHYVBVBR-PMEPUXBANA-N

SMILES

[C@@H](C12CC3CC(CC(C3)(O)C1)C2)(N)C(N1[C@@H](C[C@@H]2C[C@H]12)C#N)=O.Cl |&1:0,15,17,19,r|

Saxagliptin hydrochloride Usage And Synthesis

Description

Saxagliptin (709031-78-7) is a clinically useful DPPIV inhibitor for the treatment of diabetes.1 ?Human DPP-IV Ki = 0.6 nM.2

Uses

Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.

in vivo

IC 50

DPP-4

storage

Store at -20°C

References

[1] ABD A. TAHRANI  Anthony H B  Milan K Piya. Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus[J]. Advances in Therapy, 2009, 26 3: 249-262. DOI:10.1007/s12325-009-0014-9
[2] DAVID J. AUGERI. Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes[J]. Journal of Medicinal Chemistry, 2005, 48 15: 5025-5037. DOI:10.1021/jm050261p

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