1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(2-aMinoethoxy)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)- Chemical Properties

storage temp. 

2-8°C, protect from light

solubility 

good in water, DMSO, DMF

form 

Solid

color 

White to off-white

Appearance

white solid

InChI

InChI=1S/C14H26N4O3S/c15-5-7-21-8-6-16-12(19)4-2-1-3-11-13-10(9-22-11)17-14(20)18-13/h10-11,13H,1-9,15H2,(H,16,19)(H2,17,18,20)/t10-,11-,13-/m0/s1

InChIKey

MJCKXPHJERSYIX-GVXVVHGQSA-N

SMILES

C1(=O)N[C@]2([H])[C@H](CCCCC(NCCOCCN)=O)SC[C@]2([H])N1

1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(2-aMinoethoxy)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)- Usage And Synthesis

Description

Biotin-PEG2-amine is a diethylene glycol (PEG2) based bifunctional molecule containing biotin and a primary amino group. The reagent makes it possible to label various biomolecules (such as DNA, oligonucleotides, and proteins) with biotin by reacting the amino group with NHS esters or carboxylic acids in the presence of EDC or HATU. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection.

A short PEG2-linker separates the biotin residue from the target molecule, ensuring efficient binding to avidin or streptavidin. The linker also increases the compound’s water solubility, thereby facilitating bioconjugation.

Uses

Biotin-PEG1-NH2 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(2-aMinoethoxy)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-(811442-85-0)Related Product Information

• Biotin-PEG1-NHS ester
• Biotin-PEG5-azide
• N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE
• Biotin-PEG1-COOH
• N-(2-(2-Azidoethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
• 2-(biotinylamido)ethanol
• Biotin-PEG1-hydrazide
• Biotin-PEG5-Amine
• N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE
• 1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-,(3aS,4S,6aR)-
• Biotin-PEG4-N3
• Biotin-PEG₄-Azide
• N-Biotinyl-N'-(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine
• Biotin-PEG3-N3
• Biotin-PEG4-Alkyne
• Biotin-PEG1-oxyamine HCl salt
• Biotin-PEG1-SH
• Biotin-PEG1-TFP