1-Bromo-4-ethoxy-2,3-difluorobenzene Chemical Properties

Melting point:

31 °C

Boiling point:

222.7±35.0 °C(Predicted)

Density 

1.533±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

soluble in Methanol

form 

powder to lump

color 

White to Almost white

InChIKey

OJZVBJOHBGYINN-UHFFFAOYSA-N

Safety Information

HS Code 

2909309090

1-Bromo-4-ethoxy-2,3-difluorobenzene Usage And Synthesis

Chemical Properties

Off-white crystalline

Synthesis

To an aqueous sodium hydroxide solution (400 ml) of 4-bromo-2,3-difluorophenol (T-1) (195.0 g), ethidium bromide (196.2 g), and tetrabutylammonium bromide (TBAB) (24.2 g) was added sodium hydroxide (75.9 g), and the reaction was heated and stirred under nitrogen protection for 6 hr at 80 °C. After completion of the reaction, extraction was carried out with heptane and the organic layer was washed sequentially with water and saturated saline. Subsequently, the organic layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give a black oily substance. The oily substance was purified by distillation to give 1-ethoxy-2,3-difluorobromobenzene (T-2) as a colorless oily liquid (230.0 g, yield: 97%).

References

[1] Patent: EP2484658, 2012, A1. Location in patent: Page/Page column 37
[2] Patent: JP5663957, 2015, B2. Location in patent: Paragraph 0137-0138; 0139

1-Bromo-4-ethoxy-2,3-difluorobenzene(156573-09-0)Related Product Information

• 4-Bromofluorobenzene
• Ethoxyamine hydrochloride
• Ethoxyquin
• 1,3-Difluorobenzene
• DIETHOXYMETHANE
• 1-(Benzyloxy)-4-bromo-2,3-difluorobenzene
• Bromine
• 1-BROMO-4-(2,2-DIETHOXYETHOXY)-2,3,5-TRIFLUOROBENZENE
• Ethoxy
• 1-BROMO-4-PENTYLOXY-2,3-DIFLUOROBENZENE
• 1-BROMO-4-PROPYLOXY-2,3-DIFLUOROBENZENE
• 1-BROMO-4-BUTOXY-2,3-DIFLUOROBENZENE
• 1-Bromo-4-ethoxy-2,3-difluorobenzene