RKI1447
RKI1447 Basic information
- Product Name:
- RKI1447
- Synonyms:
-
- CS-855
- RKI 1447; RKI1447
- RKI 1447
- RKI1447
- RKI-1447
- 1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA
- Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-
- 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447
- CAS:
- 1342278-01-6
- MF:
- C16H14N4O2S
- MW:
- 326.37
- EINECS:
- 200-256-5
- Product Categories:
-
- Inhibitors
- Mol File:
- 1342278-01-6.mol
RKI1447 Chemical Properties
- Melting point:
- >205oC (dec.)
- Density
- 1.408±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 6.36±0.70(Predicted)
- form
- Solid
- color
- Pale Yellow to Pale Beige
- InChI
- InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
- InChIKey
- GDVRVPIXWXOKQO-UHFFFAOYSA-N
- SMILES
- N(CC1=CC=CC(O)=C1)C(NC1=NC(C2C=CN=CC=2)=CS1)=O
RKI1447 Usage And Synthesis
Description
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).
Uses
RKI-1447 is a potent and selective ROCK1 and ROCK2 inhibitor with significant anti-invasive and anti-tumor activies.
References
[1] patel r a et al. , rki-1447 is a potent inhibitor of the rho-associated rock kinases with anti-invasive and antitumor activities in breast cancer. cancer res, 2012, 72(19): 5025-5034.
RKI1447Supplier
- Tel
- 021-QQ:65489617 15618227136
- Sales@ATKchemical.com
- Tel
- sales@boylechem.com
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)