Basic information Safety Supplier Related

DANSYLCADAVERINE

Basic information Safety Supplier Related

DANSYLCADAVERINE Basic information

Product Name:
DANSYLCADAVERINE
Synonyms:
  • 1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-
  • Monodansyl cadaverine, N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide, N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine
  • N-(5-Aminopentyl)-5-(dimethylamino)-1-naphthalenesulfonamide
  • Einecs 233-326-9
  • Dansylcadaverine [N-(5-AMinopentyl)-5-diMethylaMinonaphthalen-1-sulfonaMide]
  • N-(5-Amino-pentyl)-5-di-methyl-amino-naphtha-lene-1-sulfon-amide
  • N-(Dimethyl-amino-naphtha-lene-sulfonyl)-1
  • 5-
CAS:
10121-91-2
MF:
C17H25N3O2S
MW:
335.46
EINECS:
233-326-9
Product Categories:
  • Naphthalene
Mol File:
10121-91-2.mol
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DANSYLCADAVERINE Chemical Properties

Melting point:
137-140 °C
Boiling point:
505.5±60.0 °C(Predicted)
Density 
1.190±0.06 g/cm3(Predicted)
storage temp. 
−20°C
form 
powder
pka
11.96±0.50(Predicted)
color 
Yellow to yellowish green
λmax
335 nm
BRN 
2951070
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
Biological Applications
Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson’s disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington’s disease,spinobulbar atrophy,spinocerebellar ataxia,denta
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
10-23

MSDS

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DANSYLCADAVERINE Usage And Synthesis

Description

Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.

Uses

Fluorescent substrate for the assay of transamidating enzymes.

Uses

Lysosomotropic fluorescent Probe

Uses

Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells.

Definition

ChEBI: Monodansylcadaverine is a sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. It has a role as a fluorochrome, a protective agent and an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is a sulfonamide, an aminonaphthalene, a tertiary amino compound and a primary amino compound. It is functionally related to a cadaverine.

References

1) Munafo and Colombo (2001),?A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation; Int. J. Cell Sci.,?114?3619 2) Jiang?et al. (2012),?Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy; J. Urol.,?188?1361 3) Haigler?et al.?(1980),?Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells; J. Biol. Chem., 255 1239 4) Murthy?et al. (1994),?Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase; J. Biol. Chem.,?269?22907

DANSYLCADAVERINESupplier

Beijing Ouhe Technology Co., Ltd
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010-82967028 13552068683
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2355560935@qq.com
Adamas Reagent, Ltd.
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400-6009262 16621234537
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chenyj@titansci.com
Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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ivy@hnhbsj.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-400-6206333 18521732826
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market@aladdin-e.com
Synchem OHG
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+49 5662 408730
Email
info@synchem.de