2-(4-AMino-1H-pyrazol-1-yl)ethanol Chemical Properties

Boiling point:

337.9±22.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

14.42±0.10(Predicted)

Appearance

Brown to dark brown Solid

2-(4-AMino-1H-pyrazol-1-yl)ethanol Usage And Synthesis

Synthesis

Synthesis of compound 22.2. To a 50 mL round bottom flask was added 1-(2-hydroxyethyl)-4-nitro-1H-pyrazole (100 mg, 0.64 mmol, 1.00 eq.), methanol (5 mL) and palladium carbon (20 mg). The reaction mixture was stirred at room temperature under hydrogen atmosphere for 1 hour. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to afford 70 mg (87% yield) of 2-(4-amino-1H-pyrazol-1-yl)ethanol (Compound 22.2) as an off-white oil.

References

[1] Patent: WO2016/42341, 2016, A1. Location in patent: Page/Page column 184
[2] Patent: WO2015/164374, 2015, A1. Location in patent: Paragraph 00338; 00339
[3] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0342; 0344
[4] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 00081
[5] Patent: WO2007/99326, 2007, A1. Location in patent: Page/Page column 113