BISABOLENE Chemical Properties

Boiling point:

155-157 °C

Density 

0.89

refractive index 

1.4940

FEMA 

3331 | BISABOLENE

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Benzene (Slightly), Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly)

form 

Oil

color 

A colourless, slightly viscous oil.

Odor

Pleasant, warm, sweet-spicy-balsamic odor.

Odor Type

fruity

Water Solubility 

Soluble in alcohol, water, (0.008994 mg/L @ 25°C (est)).

Sensitive 

Air Sensitive

JECFA Number

1336

LogP

6.70

CAS DataBase Reference

495-62-5(CAS DataBase Reference)

EPA Substance Registry System

Cyclohexene, 4-(1,5-dimethyl-4-hexenylidene)-1-methyl- (495-62-5)

Safety Information

RTECS 

GW6060000

TSCA 

Yes

HS Code 

2902.19.0050

Toxicity

Both the acute oral LD₅₀ value in rats and the acute dermal LD₅₀ value in rabbits exceeded 5 g/kg (Moreno, 1974).

MSDS

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BISABOLENE Usage And Synthesis

Chemical Properties

Bisabolene has a pleasant, warm, sweet-spicy-balsamic odor.

Occurrence

Reported found in bisabol myrrh, bergamot oil and essential oils of Orthodon asaroniferum, O. methylisoeugenoliferum, O. tenuicaule, Citrus medica var. acida (C. aurantifolia), Cinnomomum kanahirai; Citrus limonia form California; Illicium verum; French lavender (Lavendula vera). Also found in ginger and carrot.

Uses

γ-Bisabolene (Mixture of Isomers), is a sesquiterpene and can be extracted from?oregano and other aromatic plants. It may be a potential anticancer agent that can induce apoptosis in A549 cancer cell line.

Uses

It finds use in artificial oil of bergamot, myrrh and lemon, and is an excellent fixative for neroli bases. It performs well in soap and acts as a stable fixative. 

Preparation

Reported isolated from bisabol myrrh; also from nerolidol by dehydration (γ-form).

Definition

ChEBI: Gamma-bisabolene is a bisabolene.

Taste threshold values

Taste characteristics at 30 ppm: citrus, woody, tropical, floral, fruity, astringent and green.

Metabolism

The metabolism of monocyclic terpenes involves reduction or hydration of double bonds (Parke, 1968).

BISABOLENE(495-62-5)Related Product Information

• 2-METHYL-2-HEPTENE
• alpha-Bisabolol
• (-)-ALPHA-BISABOLOL
• β-bisabolene
• BISABOLENE
• hernandulcin
• alpha-Bisabolene,(E)-α-Bisabolene
• β2-Bisabolene
• BISABOLENE 'SO CALLED'(FOR FRAGRANCE)
• BETA-BISABOLENE
• trans-Z-.alpha.-Bisabolene epoxide
• 13-Nor-2-bisabolene-1,11-dione
• cis-Z-alpha-Bisabolene epoxide
• 12-hydroxy-E-gamma-bisabolene
• Bisabolene oxide
• (E)-alpha-bisabolene synthase
• (6R,7S)-7-Isothiocyanato-7,8-dihydro-α-bisabolene
• LABOTEST-BB LT00134663