ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Angiogenesis > Bcr-Abl inhibitors > GNF5
GNF5
GNF5 Basic information
- Product Name:
- GNF5
- Synonyms:
-
- GNF 5
- GNF5
- GNF-5
- N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
- ert-butyl 2-oxopiperidine-1-carboxylate
- GNF 5 N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
- N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-5
- GNF-5, >=98%
- CAS:
- 778277-15-9
- MF:
- C20H17F3N4O3
- MW:
- 418.37
- EINECS:
- 200-256-5
- Product Categories:
-
- Inhibitors
- Mol File:
- 778277-15-9.mol
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GNF5 Chemical Properties
- Boiling point:
- 612.4±55.0 °C(Predicted)
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: soluble10mg/mL (clear solution)
- pka
- 13.36±0.46(Predicted)
- form
- powder
- color
- white to beige
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GNF5 Usage And Synthesis
Uses
GNF-5 is a selective and allosteric Bcr-Abl inhibitor. It is a COVID19-related research product.
Biological Activity
GNF-5 is a BRC-Abl inhibitor.
in vivo
GNF-5 (5 mg/kg iv. or 20 mg/kg oral) has suitable pharmacokinetic parameters[1].
GNF-5 (oral, 50 or 100 mg/kg, twice daily, for 7 days) shows efficacious in vivo but can observe relapses[1].
GNF-5 (75 mg/kg, b.i.d) inhibits T315I Bcr-Abl combination with nilotinib in vivo[1].
| Animal Model: | Male Balb/c mice[1] | ||||||||||||||||
| Dosage: | 5 mg/kg, 20 mg/kg | ||||||||||||||||
| Administration: | 5 mg/kg intravenously or 20 mg/kg orally | ||||||||||||||||
| Result: |
|
| Animal Model: | p210 xenograft model[1] |
| Dosage: | 50 or 100 mg/kg |
| Administration: | oral, twice daily, for 7 days |
| Result: | Could normalize blood counts and spleen size. |
| Animal Model: | Bone marrow transduction/transplantation model[1] |
| Dosage: | 75 mg/kg |
| Administration: | twice daily |
| Result: | Showed no significant response (alone). Showed no toxicity and had a strong and sustained inhibition of Bcr-Abl-mediated signaling combination with nilotinib. |
storage
Store at +4°C
GNF5Supplier
Shanghai Boyle Chemical Co., Ltd.
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- sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
- info@chemexpress.com
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
- Tel
- 13816107857
- sales@fortunechem-sh.com
AdooQ BioScience, LLC
- Tel
- +1 (866) 930-6790
- info@adooq.com
CEG Chemical Science&Technology Co., Ltd.
- Tel
- Mobile:13665161512