PF 04995274
PF 04995274 Basic information
- Product Name:
- PF 04995274
- Synonyms:
-
- PF 04995274
- 4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol
- PF04995274;PF 04995274
- 2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-
- PF-04995274 >=98% (HPLC)
- Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
- (R)-4-((4-(((4-((Tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol
- CAS:
- 1331782-27-4
- MF:
- C23H32N2O6
- MW:
- 432.51
- Mol File:
- 1331782-27-4.mol
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PF 04995274 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
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PF 04995274 Usage And Synthesis
Description
PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.
PF 04995274Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Taizhou Tongxin Bio-Tech Co., Ltd
- Tel
- 0523-18601685-898 18652728585
- sales@allyrise.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Taizhou Ruixin Chemical Co., Ltd.
- Tel
- 0576-89085261 15867635987
- jasonhu09@163.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
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