Basic information Safety Supplier Related

PF 04995274

Basic information Safety Supplier Related

PF 04995274 Basic information

Product Name:
PF 04995274
Synonyms:
  • PF 04995274
  • 4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol
  • PF04995274;PF 04995274
  • 2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-
  • PF-04995274 >=98% (HPLC)
  • Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
CAS:
1331782-27-4
MF:
C23H32N2O6
MW:
432.51
Mol File:
1331782-27-4.mol
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PF 04995274 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM)
form 
A crystalline solid
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PF 04995274 Usage And Synthesis

Description

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.

PF 04995274Supplier

Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
Taizhou Tongxin Bio-Tech Co., Ltd
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0523-18601685-898 18652728585
Email
sales@allyrise.com
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
Taizhou Ruixin Chemical Co., Ltd.
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0576-89085261 15867635987
Email
jasonhu09@163.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
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PF 04995274(1331782-27-4)Related Product Information