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Cinacalcet IMpurity 9

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Cinacalcet IMpurity 9 Basic information

Product Name:
Cinacalcet IMpurity 9
Synonyms:
  • (αR)-5,6-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine
  • Cinacalcet impurity 13/Cinacalcet Dihydro Impurity 2 HCl/(R)-N-(1-(5,6-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl) phenyl)propan-1-amine hydrochloride
  • Cinacalcet-13
  • (R)-N-(1-(5,6-dihydronaphthalen-1-yl)ethyl)-
  • N-[(1R)-1-(5,6-dihydronaphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
  • N-(1-(7,8-dihydrophthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-aminehydrochloride
  • Cinacalcet Dihydro Impurity 2 HCl
  • 1-Naphthalenemethanamine, 5,6-dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, (αR)-
CAS:
802918-36-1
MF:
C22H24F3N
MW:
359.44
Mol File:
802918-36-1.mol
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Cinacalcet IMpurity 9 Chemical Properties

Boiling point:
433.5±45.0 °C(Predicted)
Density 
1.138±0.06 g/cm3(Predicted)
pka
9.46±0.29(Predicted)
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Cinacalcet IMpurity 9 Usage And Synthesis

Uses

(αR)-5,6-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine is synthetically prepared though a double bond migration in Heck reaction during the preparation of cinacalcet congeners. This enantiomerically pure material is seperated from its counter part, (αR)-7,8-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine (D455330) using HPLC.

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