SP-420 Chemical Properties

Melting point:

82-83℃ (ethyl acetate hexane )

Boiling point:

562.2±60.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 15mg/mL; Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL

form 

A crystalline solid

pka

1.02±0.40(Predicted)

color 

Light yellow to khaki

SP-420 Usage And Synthesis

Description

SP 420 is an iron chelator and a derivative of desferrothiocin. It induces iron excretion in rat bile and urine with an iron-clearing efficiency (ICE) value of 26.7% when administered at a dose of 300 μmol/kg and decreases iron levels in rat liver and heart at 384 μmol/kg per day. SP 420 (75 μmol/kg) also induces iron excretion in iron-overloaded C. apella monkeys (ICE = 26.3%).

Uses

Petadeferitrin is a tridentate iron chelator belonging to the class of iron chelators, with oral activity. Petadeferitrin can be used in research related to β-thalassemia[1][2][3].

in vivo

References

[1] Bergeron RJ, et al. Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles. J Med Chem. 2012 Aug 23;55(16):7090-103. DOI:10.1021/jm300509y
[2] Basu S, et al. Understanding the intricacies of iron overload associated with β-thalassemia: a comprehensive review[J]. Thalassemia Reports, 2023, 13(3): 179-194.
[3] Taher A T, et al. Safety and pharmacokinetics of the oral iron chelator SP‐420 in β‐thalassemia[J]. American Journal of Hematology, 2017, 92(12): 1356-1361. DOI:10.1002/ajh.24914