Mps1-IN-2 Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

crystalline solid

color 

Light brown to brown

Mps1-IN-2 Usage And Synthesis

Uses

Mps1-IN-2 is a novel Mps1 inhibitor.

Definition

ChEBI: Mps1-IN-2 is a member of piperidines.

Biological Activity

mps1-in-2 is a potent and selective atp-competitive inhibitor of mps1 kinase with the ic50 value of 145nm [1].mps1-in-2 has been reported to inhibit mps1 kinase activity with the ic50 value of 145nm, when screened at 1μm atp. in addition, mps1-in-2 has shown greater than 1000-fold selectivity to the alk and ltk enzyme. moreover, mps1-in-2 has been revealed to bound to the atp biding pocket of mpa1 and formed a hydrogen bond with the hinge backbone (glu603) at 2.74-å resolution. mps1-in-2 has been noted to abrogate sac function and override the checkpoint through direct inhibition of mps1[1].

IC 50

Mps1: 12 nM (Kd); GAK: 140 nM (Kd); PLK1: 61 nM (Kd); PLK3: 1600 nM (Kd); PLK4: 3100 nM (Kd); STK33: 5000 nM (Kd)

References

[1] kwiatkowski n1, jelluma n, filippakopoulos p, soundararajan m, manak ms, kwon m, choi hg, sim t, deveraux ql, rottmann s, pellman d, shah jv, kops gj, knapp s, gray ns. small-molecule kinase inhibitors provide insight into mps1 cell cycle function. nat chem biol. 2010 may;6(5):359-68. doi: 10.1038/nchembio.345. epub 2010 apr 11.