Uridine-5-oxyacetic acid methyl ester Usage And Synthesis

Uses

Uridine 5-oxyacetic acid methyl ester is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Definition

ChEBI: A methyl ester that is uridine which is substituted at position 5 on the uracil ring by a methoxycarbonylmethoxy group.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

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