Basic information Safety Supplier Related

PSI-7976

Basic information Safety Supplier Related

PSI-7976 Basic information

Product Name:
PSI-7976
Synonyms:
  • PSI-7976
  • N-[[P(R),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester
  • Sofosbuvir (R)-Phosphate
  • (S)-isopropyl 2-((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
  • isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-Lalaninate
  • L-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester
  • isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alanite
  • Sofosbuvir impurity 14/ RP-Isomer of Sofosbuvir/Isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
CAS:
1190308-01-0
MF:
C22H29FN3O9P
MW:
529.45
Mol File:
1190308-01-0.mol
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PSI-7976 Chemical Properties

Melting point:
76-82°C
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Aceatae (Slightly)
pka
9.39±0.10(Predicted)
form 
Solid
color 
White to Off-White
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PSI-7976 Usage And Synthesis

Uses

Sofosbuvir (R)-Phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

PSI-7976Supplier

JiNan QiYuan Biotechnology Co., Ltd Gold
Tel
18766124282; 18766124282
Email
18766124282@163.COM
Shandong Boluoda Biological Technology Co., Ltd. Gold
Tel
0531-58188909
Email
3007997694@qq.com
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn