4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE Chemical Properties

Melting point:

85-87 °C (lit.)

Boiling point:

85-86 °C

Density 

1.631±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder to crystal

pka

-3.11±0.10(Predicted)

color 

White to Light yellow to Light orange

BRN 

475870

InChI

InChI=1S/C5H2F4N2/c6-1-3(10)2(7)5(9)11-4(1)8/h(H2,10,11)

InChIKey

PLVFNMQHMRRBAA-UHFFFAOYSA-N

SMILES

C1(F)=NC(F)=C(F)C(N)=C1F

CAS DataBase Reference

1682-20-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE Usage And Synthesis

Synthesis

In principle, ammonia could be used to allow indirect replacement of fluorine by hydrogen. Workers in this laboratory showed that pentafluoropyridine reacted with ammonia giving 4-aminotetrafluoropyridine.

Chemical Properties

white to light yellow crystal

General Description

4-Amino-2,3,5,6-tetrafluoropyridine is formed as C-H ′insertion′ product during reaction with 4-azido-2,3,5,6-tetrafluoropyridine.

References

[1] Journal of Fluorine Chemistry, 1996, vol. 81, # 1, p. 39 - 42
[2] Journal of the American Chemical Society, 2017, vol. 139, # 37, p. 13092 - 13101
[3] Oriental Journal of Chemistry, 2016, vol. 32, # 4, p. 1799 - 1813
[4] Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 12, p. 2267 - 2272
[5] Zhurnal Organicheskoi Khimii, 1988, vol. 24, # 12, p. 2513 - 2518

4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE(1682-20-8)Related Product Information

• 2,3,4,5,6-Pentafluoroaniline
• 4-Amino-3,5-dichloro-2,6-difluoropyridine
• 4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE
• 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE
• 2,3,5,6-Tetrafluoropyridine
• 2,3,5,6-TETRAFLUORO-4-NITROPYRIDINE
• 2,3,5,6-TETRAFLUORO-4-HYDRAZINOPYRIDINE
• N-[(4-FLUOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE
• 4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-{[2-(TRIFLUOROMETHYL)PHENYL]SULFONYL}PIPERAZINE-1-CARBOXAMIDE
• 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[2-(TRIFLUOROMETHYL)PHENYL]HYDRAZINECARBOXAMIDE
• 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[3-(TRIFLUOROMETHYL)PHENYL]HYDRAZINECARBOXAMIDE
• N-[2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE
• N-{[2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE
• N-[(3,4-DICHLOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE
• 4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-{[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}PIPERAZINE-1-CARBOXAMIDE
• N-[(3,5-DICHLOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE
• 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[4-(TRIFLUOROMETHOXY)PHENYL]HYDRAZINECARBOTHIOAMIDE
• 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINECARBOXAMIDE