RONIDAZOLE
RONIDAZOLE Basic information
- Product Name:
- RONIDAZOLE
- Synonyms:
-
- 1-METHYL-2-[CARBAMOYLOXYMETHYL]-5-NITROIMIDAZOLE
- TIMTEC-BB SBB006916
- RONIDAZOL
- RONIDAZOLE
- 1-methyl-5-nitro-1h-imidazole-2-methanocarbamate(ester)
- 1-methyl-5-nitro-1h-imidazole-2-methanolcarbamateester
- 1-methyl-5-nitro-imidazole-2-methanocarbamate(ester)
- dugro
- CAS:
- 7681-76-7
- MF:
- C6H8N4O4
- MW:
- 200.15
- EINECS:
- 231-675-1
- Product Categories:
-
- ANCEF
- Amines
- Heteroyclces
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 7681-76-7.mol
RONIDAZOLE Chemical Properties
- Melting point:
- 167-169°
- Boiling point:
- 337.86°C (rough estimate)
- Density
- 1.5359 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- −20°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 1.2(at 25℃)
- form
- Solid
- color
- Pale Yellow
- InChI
- InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)
- InChIKey
- PQFRTXSWDXZRRS-UHFFFAOYSA-N
- SMILES
- C1(COC(=O)N)=NC=C([N+]([O-])=O)N1C
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 2
- RTECS
- NI6803000
- HS Code
- 29332900
MSDS
- Language:English Provider:SigmaAldrich
RONIDAZOLE Usage And Synthesis
Brand Name(s)
Flagyl and generic
Uses
Antimicrobial.
Uses
antibacterial
Definition
ChEBI: Ronidazole is a carbamate ester that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl and (carbamoyloxy)methyl groups, respectively. An antiprotozoal agent, it is used in veterinary medicine for the treatment of histomoniasis and swine dysentery. It has a role as an antiprotozoal drug and an antiparasitic agent. It is a member of imidazoles, a carbamate ester and a C-nitro compound.
Veterinary Drugs and Treatments
Ronidazole is a nitroimidazole antibiotic/antiparasitic drug that appears to be useful in treating Tritrichomonas foetus infections in cats. The drug is not commercially available in the USA and must be compounded from bulk powder by a compounding pharmacy. The drug is also used for treating Trichomonas infections in nonfood animal birds.
in vivo
Pharmacokinetic Analysis in six cats[3]
| Drug administration | Dose (mg/kg) | T1/2 (K) (h) | C0 (μg/mL) | AUC 0-∞ (h?μg/m) | Vd or Vd/F (mL/kg) | Clearance or CL/F (h) | MRT (h) | Tmax (h) | Cmax (μg/m) | F (%) |
| i.v. | 9.175 | 9.80 | 13.27 | 187.30 | 700 | 0.82 | 14.14 | NA | NA | NA |
| p.o. | 28.23 | 10.50 | NA | 566.98 | 770 | 0.84 | NA | 1.02 | 35.37 | 99.64 |
| Animal Model: | CDI mice model[2] |
| Dosage: | 1 mg/kg, 10mg/kg |
| Administration: | Oral gavage |
| Result: | Both 1 mg/kg and 10 mg/kg Ronidazole protected 60% of mice from infection |
RONIDAZOLESupplier
- Tel
- 18210857532; 18210857532
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- Tel
- 0757-86329057 18934348241
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- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- info@syntechem.com
- Tel
- 400-1166-196 18981987031
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RONIDAZOLE(7681-76-7)Related Product Information
- Cefmetazole
- methylol cellulose
- Pyrimethanil
- Nitazoxanide
- alpha,2-Dimethyl-5-nitro-1H-imidazole-1-ethanol
- (-)-MENTHYL CHLOROFORMATE
- Acetamide
- 1-METHYL-5-NITROIMIDAZOLE
- 1,2-Dimethyl-5-nitroimidazole
- RONIDAZOLE
- 1-Methyl-5-nitro-1H-imidazole-2-methanol
- (1-Methyl-1H-imidazol-2-yl)methanol
- 2-Methyl-4-nitroimidazole
- Ronidazole-d3
- 1H-IMIDAZOL-2-YLMETHANOL HYDROCHLORIDE
- 2-CARBAMOYLOXYMETHYL-1-METHYL-D3-5-NITRO-1H-IMIDAZOLE(RONIDAZOLE-D3)
- 2-CARBAMOYLOXYMETHYL-1-METHYL-5-NITRO-1H-IMIDAZOLE(RONIDAZOLE)