LY 456236
LY 456236 Basic information
- Product Name:
- LY 456236
- Synonyms:
-
- (4-Methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine hydrochloride
- LY456236 HCl
- LY 456236, mGlu1 non competitive antagonist
- CAS:
- 338736-46-2
- MF:
- C16H16ClN3O2
- MW:
- 317.77
- Product Categories:
-
- Agonist, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- 338736-46-2.mol
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LY 456236 Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble2mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
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LY 456236 Usage And Synthesis
Uses
LY 456236 is a mGlu1 receptor antagonists, which may be used in the treatment of chronic pain and epilepsy and other seizure disorders.
in vivo
LY456236 shows anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once)[3].
| Animal Model: | DBA/2 mice and CD1 mice, seizure models[3] |
| Dosage: | 3-100 mg/kg |
| Administration: | IP, once |
| Result: | Produced dose-related anticonvulsant effects in preventing audiogenic-induced (tonic-clonic) seizures in DBA/2 mice, threshold electroshock-induced seizures in CD1 mice, and 6 Hz electroshock-induced seizures in CD1 mice. |
| Animal Model: | Amygdala-kindled Sprague-Dawley rats[3] |
| Dosage: | 10, 30 and 60 mg/kg |
| Administration: | Oral, once |
| Result: | Produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. Produced a dose-related increase in the stimulus intensity required to produce generalized seizures. |
storage
Desiccate at RT
LY 456236Supplier
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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- 021-33632979
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ELSA BIOTECHNOLOGY CO.,LTD.
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- 15261860116
- sales@elsa-biotech.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
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Shanghai Yunpun industrial Co.,Ltd
- Tel
- 21-61726900 15202122459
- sales@yunpun.com