GSK2141795
GSK2141795 Basic information
- Product Name:
- GSK2141795
- Synonyms:
-
- GSK2141795
- Uprosertib
- Uprosertib(GSK2141795)
- Uprosertib , GSK2141795C
- GSK 2141795C
- N-[(1S)-2-Amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide
- Uprosertib, 98%, a potent and selective pan-Akt inhibitor
- CS-1304
- CAS:
- 1047634-65-0
- MF:
- C18H16Cl2F2N4O2
- MW:
- 429.25
- Product Categories:
-
- API
- Mol File:
- 1047634-65-0.mol
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GSK2141795 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:45.33(Max Conc. mg/mL);105.6(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.33(Max Conc. mM)
Ethanol:85.0(Max Conc. mg/mL);198.02(Max Conc. mM) - form
- Powder
- color
- White to off-white
- InChI
- InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
- InChIKey
- AXTAPYRUEKNRBA-JTQLQIEISA-N
- SMILES
- O1C(Cl)=C(C2N(C)N=CC=2Cl)C=C1C(N[C@@H](CC1=CC=C(F)C(F)=C1)CN)=O
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GSK2141795 Usage And Synthesis
Uses
Uprosertib is a potent and selective inhibitor of pan-Akt (1). Serine/threonine protein kinases, such as Akt, play important roles in cellular activities including cell survival and apoptosis.
IC 50
Akt3: 38 nM (IC50); Akt1: 180 nM (IC50); Akt2: 328 nM (IC50); ROCK1: 1570 nM (IC50); ROCK2: 1850 nM (IC50); CDK7: 2100 nM (IC50)
GSK2141795Supplier
Changzhou Chenhong Biotechnology Co., Ltd. Gold
- Tel
- +86-0519-85788828 +86-13775037613
- sales@chemrenpharm.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn