3-Methoxy-5-nitrobenzotrifluoride Chemical Properties

Melting point:

36-38 °C (lit.)

Boiling point:

246.9±40.0 °C(Predicted)

Density 

1.392±0.06 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

solid

color 

Low-mwlting

CAS DataBase Reference

328-79-0(CAS DataBase Reference)

NIST Chemistry Reference

3-Methoxy-5-nitrobenzotrifluoride(328-79-0)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36/38-21/22

Safety Statements 

26-27-28-36/37/39-45

RIDADR 

UN 1759 8/PG 2

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

III

HS Code 

2909309090

MSDS

• Language:English Provider:SigmaAldrich

3-Methoxy-5-nitrobenzotrifluoride Usage And Synthesis

Uses

3-Methoxy-5-nitrobenzotrifluoride may be used in chemical synthesis.

Synthesis

To a solution of 3,5-dinitrobenzotrifluoride (10 g, 42.4 mmol) in anhydrous methanol (100 mL) was slowly added a solution of sodium methanolate (3.43 g, 63.5 mmol) in anhydrous methanol (20 mL). The reaction mixture was heated to reflux for 1 hour and subsequently concentrated by rotary evaporation to remove the methanol solvent. The concentrated residue was diluted with ethyl acetate (80 mL) and water (30 mL) to separate the organic phase. The organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give 3-nitro-5-(trifluoromethyl)anisole (8.5 g) as a red solid. The product was analyzed by LC-MS (ESI): no [M + H]+ peak was observed; retention time was 1.85 min.

References

[1] Journal of the Chemical Society, 1951, p. 2013,2016
[2] Journal of the American Chemical Society, 1955, vol. 77, p. 2284,2285
[3] Patent: WO2013/13503, 2013, A1. Location in patent: Page/Page column 43

3-Methoxy-5-nitrobenzotrifluoride(328-79-0)Related Product Information

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• TRITON
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• 4-Methoxy-3-nitrobenzotrifluoride98%,4-METHOXY-3-NITROBENZOTRIFLUORIDE,4-METHOXY-3-NITROBENZOTRIFLUORIDE 99%
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