para-Hydroxy Atorvastatin CalciuM Salt
para-Hydroxy Atorvastatin CalciuM Salt Basic information
- Product Name:
- para-Hydroxy Atorvastatin CalciuM Salt
- Synonyms:
-
- Atorvastatin impurity 35/para-Hydroxy Atorvastatin Calcium Salt/(3R,5R)-7-[2-(4-fluorophenyl)-4-[(4-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate Calcium Salt
- Atorvastatin Impurity 52
- 4-Hydroxy Atorvastatin HeMicalciuM Salt
- 4-Hydroxy Atorvastatin
- Atorvastatin Impurity J
- Para-Hydroxy Atorvastatin Calcium
- Atorvastatin Impurity 154
- calcium,(3S,5S)-7-[2-(4-fluorophenyl)-4-[(4-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
- CAS:
- 265989-44-4
- MF:
- C66H70CaF2N4O12
- MW:
- 1189.3564064
- Mol File:
- 265989-44-4.mol
para-Hydroxy Atorvastatin CalciuM Salt Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.5 mg/ml
- form
- A crystalline solid
para-Hydroxy Atorvastatin CalciuM Salt Usage And Synthesis
Description
4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.1,2,3,4 Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin.1
References
1. Hong, J.H., Youm, J.K., Kwon, M.J., et al. K6PC-
2. Dart, A., Jerums, G., Nicholson, G., et al. A multicenter, double-
3. Group, T.D.A.L.I.S. The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia. The DALI study: A double-
4. van Dam, M., Zwart, M., de Beer, F., et al. Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia Heart 88(3),234-238(2002).
para-Hydroxy Atorvastatin CalciuM SaltSupplier
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para-Hydroxy Atorvastatin CalciuM Salt(265989-44-4)Related Product Information
- P-HYDROXY ATORVASTATIN LACTONE
- Atorvastatin Impurity 31
- Difluoro Atorvastatin Acetonide tert-Butyl Ester
- 2,3-Dehydroxy Atorvastatin Sodium Salt
- Atorvastatin IMpurity G
- Ortho-Hydroxy atorvastatin calcium salt
- 4-Hydroxy Atorvastatin Lactone-d5
- para-Hydroxy Atorvastatin-d5 CalciuM Salt
- Dihydroxy Diketo Atorvastatin IMpurity
- 5-Oxo Atorvastatin tert-Butyl Ester
- Atorvastatin Impurity 46
- Atorvastatin Impurity 38
- Atorvastatin
- 3-Oxo Atorvastatin tert-Butyl Ester
- Atorvastatin Impurity 15
- 2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide
- Atorvastatin Dehydro Lactone
- Atorvastatin Impurity 20