Basic information Safety Supplier Related

para-Hydroxy Atorvastatin CalciuM Salt

Basic information Safety Supplier Related

para-Hydroxy Atorvastatin CalciuM Salt Basic information

Product Name:
para-Hydroxy Atorvastatin CalciuM Salt
Synonyms:
  • Atorvastatin impurity 35/para-Hydroxy Atorvastatin Calcium Salt/(3R,5R)-7-[2-(4-fluorophenyl)-4-[(4-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate Calcium Salt
  • Atorvastatin Impurity 52
  • 4-Hydroxy Atorvastatin HeMicalciuM Salt
  • 4-Hydroxy Atorvastatin
  • Atorvastatin Impurity J
  • Para-Hydroxy Atorvastatin Calcium
  • Atorvastatin Impurity 154
  • calcium,(3S,5S)-7-[2-(4-fluorophenyl)-4-[(4-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
CAS:
265989-44-4
MF:
C66H70CaF2N4O12
MW:
1189.3564064
Mol File:
265989-44-4.mol
More
Less

para-Hydroxy Atorvastatin CalciuM Salt Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.5 mg/ml
form 
A crystalline solid
More
Less

para-Hydroxy Atorvastatin CalciuM Salt Usage And Synthesis

Description

4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.1,2,3,4 Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin.1

References

1. Hong, J.H., Youm, J.K., Kwon, M.J., et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling J. Invest. Dermatol. 128,2166-2178(2008).
2. Dart, A., Jerums, G., Nicholson, G., et al. A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients with hypercholesterolemia Am. J. Cardiol. 80(1),39-44(1997).
3. Group, T.D.A.L.I.S. The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia. The DALI study: A double-blind, randomized, placebo-controlled trial in patients with type 2 diabetes and diabetic dyslipidemia Diabetes Care 24(8),1335-1341(2001).
4. van Dam, M., Zwart, M., de Beer, F., et al. Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia Heart 88(3),234-238(2002).

para-Hydroxy Atorvastatin CalciuM SaltSupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Cato Research Chemicals Inc.
Tel
020-81960175
Email
min.he@cato-chem.com
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Email
sales@chem-strong.com