para-Hydroxy Atorvastatin CalciuM Salt Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.5 mg/ml

form 

A crystalline solid

InChIKey

ANSBACJULZIWOU-DJNTWTPDSA-N

para-Hydroxy Atorvastatin CalciuM Salt Usage And Synthesis

Uses

4-Hydroxyatorvastatin (calcium salt) can be used as a pharmaceutical intermediate for the synthesis of atorvastatin calcium.

Description

4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.^1,2,3,4 Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin.¹

References

1. Hong, J.H., Youm, J.K., Kwon, M.J., et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca²⁺ signaling J. Invest. Dermatol. 128,2166-2178(2008).
2. Dart, A., Jerums, G., Nicholson, G., et al. A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients with hypercholesterolemia Am. J. Cardiol. 80(1),39-44(1997).
3. Group, T.D.A.L.I.S. The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia. The DALI study: A double-blind, randomized, placebo-controlled trial in patients with type 2 diabetes and diabetic dyslipidemia Diabetes Care 24(8),1335-1341(2001).
4. van Dam, M., Zwart, M., de Beer, F., et al. Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia Heart 88(3),234-238(2002).

para-Hydroxy Atorvastatin CalciuM Salt(265989-44-4)Related Product Information

• P-HYDROXY ATORVASTATIN LACTONE
• Atorvastatin Impurity 31
• Difluoro Atorvastatin Acetonide tert-Butyl Ester
• 2,3-Dehydroxy Atorvastatin Sodium Salt
• Atorvastatin IMpurity G
• Ortho-Hydroxy atorvastatin calcium salt
• 4-Hydroxy Atorvastatin Lactone-d5
• para-Hydroxy Atorvastatin-d5 CalciuM Salt
• Dihydroxy Diketo Atorvastatin IMpurity
• 5-Oxo Atorvastatin tert-Butyl Ester
• Atorvastatin Impurity 46
• Atorvastatin Impurity 38
• Atorvastatin
• 3-Oxo Atorvastatin tert-Butyl Ester
• Atorvastatin Impurity 15
• 2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide
• Atorvastatin Dehydro Lactone
• Atorvastatin Impurity 20