ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Protein tyrosine kinase /JAK / STAT > STAT inhibitors > HO-3867
HO-3867
HO-3867 Basic information
- Product Name:
- HO-3867
- Synonyms:
-
- HO-3867 (HO 3867
- CS-2205
- (3E,5E)-3,5-Bis(4-fluorobenzylidene)-1-[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-4-piperidinone
- HO-3867
- 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-(3E,5E)-4-piperidinone
- (3E,5E)-1-[(2,5-Dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone
- 4-Piperidinone, 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-, (3E,5E)-
- HO-3867 USP/EP/BP
- CAS:
- 1172133-28-6
- MF:
- C28H30F2N2O2
- MW:
- 464.55
- Product Categories:
-
- Inhibitors
- Mol File:
- 1172133-28-6.mol
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HO-3867 Chemical Properties
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥18.15 mg/mL in DMSO
- form
- solid
- color
- Light yellow to yellow
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HO-3867 Usage And Synthesis
Uses
HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor activity.
IC 50
STAT3
References
[1] Rath KS et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15;74(8):2316-27. DOI:10.1158/0008-5472.CAN-13-2433
[2] Hu Y, et al. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anticancer Drugs. 2017 Apr;28(4):392-400. DOI:10.1097/CAD.0000000000000470
[3] Tierney BJ et al. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer Biol Ther. 2012 Jul;13(9):766-75 DOI:10.4161/cbt.20559
HO-3867Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
AdooQ BioScience, LLC
- Tel
- +1 (866) 930-6790
- info@adooq.com
Bide Pharmatech Ltd.
- Tel
- 400-164-7117 13681763483
- product02@bidepharm.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn