MPEG3-Propyne Chemical Properties

Boiling point:

94-99 °C(Press: 0.01 Torr)

Density 

0.997±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, stored under nitrogen

form 

liquid

color 

Clear

Safety Information

HS Code 

2942000090

MPEG3-Propyne Usage And Synthesis

Description

Propargyl-PEG4-methane is a crosslinking reagent that can react with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry to yield a stable triazole linkage.

Uses

Propargyl-PEG3-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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