MK-4827 (R-enantioMer) Chemical Properties

Boiling point:

463.6±45.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 32 mg/mL (99.88 mM)

pka

15.36±0.30(Predicted)

MK-4827 (R-enantioMer) Usage And Synthesis

Uses

ent-Niraparib is an isomer of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Definition

ChEBI: 2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has R-configuration. It is a potent PARP1 inhibitor with IC50 of 2.4 nM. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an antineoplastic agent.

MK-4827 (R-enantioMer)(1038915-58-0)Related Product Information

• Niraparib
• Niraparib tosylate
• MK-4827 (tosylate)
• (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide