SELEXIPAG interMediate Chemical Properties

Melting point:

68 - 71°C

Boiling point:

514.4±50.0 °C(Predicted)

Density 

1.112±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly)

pka

15.05±0.10(Predicted)

form 

Solid

color 

Pale Yellow to Light Yellow

SELEXIPAG interMediate Usage And Synthesis

Uses

4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-butanol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is an impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.

Application

Selexipag interMediate is a synthetic organic compound that is used as an intermediate in the synthesis of oxychloride. It is an oxychloride with a nucleophilic substitution reaction. The reaction proceeds selectively at the phosphorus atom and gives high yield. The reactivity of 4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butan-1-ol is enhanced by the use of n butanol, which also acts as a solvent for the reaction. The product can be purified by filtration or recrystallization from hexane with piperazine as a reagent.

SELEXIPAG interMediate(475086-75-0)Related Product Information

• 5-chloro-2,3-diphenylpyrazine
• ( 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butylester )
• [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
• 2,3-DIPHENYLPYRAZINE
• Bromoacetic acid
• 2-T-BUTYL GLYCOLATE
• 4-(Isopropylamino)butanol
• 5,6-DIPHENYLPYRAZIN-2-OL
• N-(methylsulfonyl)glycine
• 2,3-Dichloro-5,6-diphenylpyrazine
• Cefepime
• Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-
• 2-Pyrazinamine, N-(1-methylethyl)-5,6-diphenyl-
• 1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)oxy]-
• Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-, 1,1-dimethylethyl ester
• Acetamide, 2-[4-[(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)-
• Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-