ChemicalBook > Product Catalog > Organic Chemistry > Heterocyclic Compounds > N-succiniMidyl 4-(2-pyridyldithio)pentanoate
N-succiniMidyl 4-(2-pyridyldithio)pentanoate
N-succiniMidyl 4-(2-pyridyldithio)pentanoate Basic information
- Product Name:
- N-succiniMidyl 4-(2-pyridyldithio)pentanoate
- Synonyms:
-
- 4-(Pyridin-2-yldisulfanyl)pentanoic acid N-Hydroxy succinimide ester
- N-succinimidyl 4-(2-pyridyldithio)-pentanoate / SPP
- N-succiniMidyl 4-(2-pyridyldithio)pentanoate
- 2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfaneyl)pentanoate
- 2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)pentanoate
- Pentanoic acid, 4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
- CAS:
- 341498-08-6
- MF:
- C14H16N2O4S2
- MW:
- 340.41784
- EINECS:
- 636-474-6
- Mol File:
- 341498-08-6.mol
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N-succiniMidyl 4-(2-pyridyldithio)pentanoate Chemical Properties
- Melting point:
- 48-49 °C
- Boiling point:
- 483.5±55.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Storage temp. -20°C
- pka
- 1.83±0.19(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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N-succiniMidyl 4-(2-pyridyldithio)pentanoate Usage And Synthesis
Uses
SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1].
IC 50
Cleavable Linker; Disulfide Cleavable Linker
References
[1] Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. DOI:10.1021/mp5007757
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