Basic information Safety Supplier Related

Polygalasaponin XXXI

Basic information Safety Supplier Related

Polygalasaponin XXXI Basic information

Product Name:
Polygalasaponin XXXI
Synonyms:
  • Onjisaponin F
  • Polygalasaponin XXXI
  • Onjisaponin F Polygalasaponin XXXI
  • Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, 28-[O-D-apio-β-D-furanosyl-(1→3)-O-[O-α-L-arabinopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)]-O-6-deoxy-α-L-mannopyranosyl-(1→2)-6-deoxy-4-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-β-D-galactopyranosyl] ester, (2β,3β...
  • Polygalasaponin XXX
  • (2S,3R,4S,4aR,6aR,6bR,8aS,12aS,14aR,14bR)-8a-((((2S,3R,4S,5R,6R)-3-(((2S,3R,4S,5S,6S)-5-(((2S,3R,4S,5R)-3,5-Dihydroxy-4-(((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4-(((2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyl-5-(((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)tetrahydro-2H-pyran-2-yl)oxy)carbonyl)-2-hydroxy-6b-(hydroxymethyl)-4,6a,11,11,14b-pentamethyl-3-(((2R,
CAS:
79103-90-5
MF:
C75H112O36
MW:
1589.69
Mol File:
79103-90-5.mol
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Polygalasaponin XXXI Chemical Properties

Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
4.14±0.70(Predicted)
color 
White to off-white
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Polygalasaponin XXXI Usage And Synthesis

Uses

Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1].

Definition

ChEBI: Onjisaponin F is a triterpenoid saponin.

in vivo

Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1].

target

cAMP

References

[1] T Nagai, et al. Onjisaponins, From the Root of Polygala Tenuifolia Willdenow, as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34. DOI:10.1016/s0264-410x(01)00215-8
[2] T Yabe, et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia, Constituents of Kampo (Japanese Herbal) Medicine, Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14. DOI:10.1078/094471103321659799

Polygalasaponin XXXISupplier

Chengdu Biopurify Phytochemicals Ltd.
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021-61317773
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