Wnt Agonist Chemical Properties

Boiling point:

623.4±65.0 °C(Predicted)

Density 

1.353±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble20mg/mL, clear

pka

6.62±0.10(Predicted)

form 

Yellowish sticky solid

color 

white to beige

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26-39

WGK Germany 

3

Wnt Agonist Usage And Synthesis

Uses

CID 11210285 hydrochloride has been used as a Wnt agonist.

Definition

ChEBI: N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine is a member of pyrimidines.

Biological Activity

wnt agonist 1 is a small-molecule agonist of wnt signaling pathway [1].the wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation [1].wnt agonist 1 is a cell-permeable wnt signaling pathway agonist. wnt agonist 1 induced b-catenin- and tcf-dependent transcriptional activity in a dose-dependent way with ec50 of 0.7 μm. in xenopus embryos, treatment with wnt agonist 1 (10 μm) from developmental stage 10.5 to stage 40 resulted in substantial head defects, such as diminished heads and complete loss of eyes, and reduced eyes and heads. this phenotype is similar to that which results from wnt over-expression in head specification during early embryonic development.

Biochem/physiol Actions

CID 11210285 is a cell-permeable, potent and selective activator of Wnt signaling without inhibiting GSK-3β. CID 11210285is a Wnt agonist.

References

liu j, wu x, mitchell b, et al. a small-molecule agonist of the wnt signaling pathway. angew chem int ed engl. 2005 mar 18;44(13):1987-90.

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